Oxandrolone Wikipedia

Oxandrolone Wikipedia

Contents

Oxandrolone

Oxandrolone is a synthetic anabolic steroid that has been used in medical settings for its ability to promote muscle growth and bone density.

Medical Uses

• Muscle wasting associated with conditions like cancer, AIDS, or prolonged bed rest.
• Bone mineral density improvement in conditions such as osteoporosis.
• Aid in the recovery process for burns and injuries.
• Supportive therapy in chronic respiratory diseases to improve body composition.

Non-Medical Uses

Oxandrolone is occasionally used illegally as a performance-enhancing drug, often by athletes seeking to build muscle without the aid of legitimate medical supervision. However, this use is typically illegal and carries serious health risks.

Contraindications

• Pregnancy: Risk to fetal development.
• Hypercalcemia (high calcium levels): Risk of exacerbating the condition.
• Pre-existing steroid-sensitive conditions or allergies: Potential for severe reactions.

Side Effects

• Acne, hair loss, and other skin changes.
• Edema (fluid retention) in some cases.
• Liver damage or dysfunction.
• Possible immune suppression effects.

Interactions

Oxandrolone may interact with other medications, such as warfarin (increased risk of bleeding), leading to potential adverse effects. Always consult a healthcare provider before using the drug in conjunction with others.

Pharmacology

Oxandrolone works by binding to androgen receptors in muscle cells, stimulating growth and protein synthesis, which leads to muscle mass gains and fat loss.

Pharmacodynamics

• Binds to the androgen receptor and activates gene transcription.
• Promotes bone formation and muscle regrowth.
• Metabolized in the liver, with a half-life of about 21 hours.

Steroid Configuration

Oxandrolone is a synthetic derivative of dihydrotestosterone (DHT), differing from other anabolic steroids like testosterone.

Chemistry

• Molecular formula: C19H28O2.
• Synthesized via various methods, often involving the reduction of DHT and subsequent functionalization.

History

Oxandrolone was first introduced in the 1960s as a therapeutic agent for muscle wasting and bone health, gaining approval from regulatory bodies for medical use.

Society and Culture

• The drug has been subject to misuse in athletic populations, often leading to legal consequences due to its classification as a controlled substance.
• Its availability varies by country, with strict regulations in place to limit non-medical use.

Generic Names

• Oxandrolona (common in some countries)

Brand Names

• Methandiol
• Steranabol
• Thalidomine
• Oxabolon

Availability

In the United States, oxandrolone is available by prescription as a generic or brand-name product, subject to strict monitoring and distribution guidelines.

Other Countries

Availability may vary by country, with some regions imposing stricter regulations on anabolic steroid distribution due to their misuse potential.

Legal Status

• In the United States: Class I controlled substance under federal law, with severe penalties for unauthorized possession or distribution.
• Varies by country; some have implemented strict scheduling to limit non-therapeutic use.

References

For detailed information, please refer to the corresponding entries in medical textbooks and pharmacopeias, such as the United States Pharmacopeia (USP) or British Pharmaceutical Codex (BPC).

External Links

• Wikipedia: Oxandrolone

References:

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