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Despite popular beliefs, the addition of excessive dosages and multiple types of AAS have not been shown to elicit a summative effect (NIDA, 2000). This practice is referred to as “stacking.” Users may take as many as six different AAS with the goal of maximizing androgen receptor (AR) binding and activating multiple steroidal receptor sites (Peters et al., 1997). Anecdotal evidence suggests that tapering off of high levels of AAS, as with many other medications, can reduce withdrawal symptoms or rebound effects; however, this has not been established scientifically (NIDA, 2000). Additionally, off-cycles are used to avoid detection during competition in drug-free athletic events.
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